CONTROL OF STEREOSELECTIVITY IN SAMARIUM METAL INDUCED CYCLOPROPANATIONS - SYNTHESIS OF 1,25-DIHYDROXYCHOLECALCIFEROL

被引：56

作者：

KABAT, M

KIEGIEL, J

COHEN, N

TOTH, K

WOVKULICH, PM

USKOKOVIC, MR

机构：

[1] Roche Research Center, Hoffmann-La Roche Inc., Nutley

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)79919-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,25-Dihydroxycholecalciferol (23) was synthesized from A-ring precursor 18 and Windaus-Grundmann ketone 19 via cyclovitamin D 21. Key reactions include highly stereoselective (5 to 6) and stereospecific (13 to 14) cyclopropanations.

引用

页码：2343 / 2346

页数：4

共 8 条

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