THE NA+-CA2+ EXCHANGER ACTIVITY IN CEREBROCORTICAL NERVE-ENDINGS IS REDUCED IN OLD COMPARED TO YOUNG AND MATURE RATS WHEN IT OPERATES AS A CA2+ INFLUX OR EFFLUX PATHWAY

被引：18

作者：

CANZONIERO, LMT ^{[1
]}

ROSSI, A ^{[1
]}

TAGLIALATELA, M ^{[1
]}

AMOROSO, S ^{[1
]}

ANNUNZIATO, L ^{[1
]}

DIRENZO, G ^{[1
]}

机构：

[1] UNIV FEDERICO II NAPLES, SCH MED 2,DEPT SCI HUMAN COMMUN,UNIT PHARMACOL, VIA S PANSINI 5, I-80131 NAPLES, ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1107卷 / 01期

关键词：

SODIUM CALCIUM ION EXCHANGER; VOLTAGE SENSITIVITY; CALCIUM ION CHANNEL; INTRACYTOSOLIC CALCIUM ION; CALCIUM ION; INTRACYTOSOLIC; AGING; CEREBROCORTICAL NERVE ENDING;

D O I：

10.1016/0005-2736(92)90344-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of the Na+-Ca2+ exchanger, which regulates the entry and the extrusion of Ca2+ ions from nerve endings was investigated in Percoll-purified cerebrocortical synaptosomes of aged rats. Ca-45(2+) uptake in a Na+-free medium and Ca-45(2+) efflux in a 145 mM Na+ medium were significantly reduced in cerebrocortical synaptosomes from aged rats (24 months) as compared to those occurring in young (4 months) and mature (14 months) rats. Ca-45(2+) influx induced by 55 mM K+, a concentration of K+ ions which selectively promotes Ca2+ entry through voltage-sensitive Ca2+ channels (VSCC), was significantly reduced in mature and aged rats as compared to that occurring in young rats. The impairment of these mechanisms in aged rats is not accompanied by any variation of fura-2 monitored Ca2+ levels under resting and depolarizing conditions.

引用

页码：175 / 178

页数：4

共 18 条

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