AUTOIMMUNE-DISEASE AND THE MAJOR HISTOCOMPATIBILITY COMPLEX - THERAPEUTIC IMPLICATIONS

被引：41

作者：

DALTON, TA ^{[1
]}

BENNETT, JC ^{[1
]}

机构：

[1] UNIV ALABAMA,SCH MED,DEPT MED,BIRMINGHAM,AL 35233

来源：

AMERICAN JOURNAL OF MEDICINE | 1992年 / 92卷 / 02期

关键词：

D O I：

10.1016/0002-9343(92)90110-W

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A hereditary basis for the predisposition to several autoimmune diseases has long been suspected. A relationship between diseases and genes that encode various immune effector proteins is now recognized. Many of these genes are components of the major histocompatibility complex (MHC). Recent studies have provided insights into the mechanism by which MHC antigens can influence the tendency to the expression of autoimmune disease. These findings have also provided the rationale for designing specific immunotherapeutic interventions.

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页码：183 / 188

页数：6

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