BILIARY RESPONSE TO GLUCAGON IN HUMANS

被引：9

作者：

BRANUM, GD ^{[1
]}

BOWERS, BA ^{[1
]}

WATTERS, CR ^{[1
]}

HAEBIG, J ^{[1
]}

CUCCHIARO, G ^{[1
]}

FAROUK, M ^{[1
]}

MEYERS, WC ^{[1
]}

机构：

[1] VET ADM MED CTR,DURHAM,NC 27705

来源：

ANNALS OF SURGERY | 1991年 / 213卷 / 04期

关键词：

D O I：

10.1097/00000658-199104000-00008

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a balloon-occludable t tube. An aliquot of the collected sample was kept and the enterohepatic circulation was maintained by reinfusion of the collected bile via the distal t-tube port. Glucagon increased bile flow and decreased cholesterol and phospholipid output during stable bile acid output. Furthermore high-performance liquid chromatographic analysis of bile acid profiles revealed no significant changes in bile salt species or conjugation after glucagon infusion. Glucagon is probably important in the physiologic regulation of biliary secretion in humans.

引用

页码：335 / 340

页数：6

共 28 条

[1] ABELL LL, 1952, J BIOL CHEM, V195, P357
[2] BILIARY RESPONSE TO GLUCAGON AND INSULIN FOLLOWING HEPATIC TRANSPLANTATION IN HUMANS
BRANUM, GD
BOWERS, BA
WATTERS, CR
CUCCHIARO, G
MEYERS, WC
[J]. JOURNAL OF SURGICAL RESEARCH, 1990, 49 (02) : 121 - 125
[3] FISHER LH, 1925, J BIOL CHEM, V66, P395
[4] FOLCH J, 1957, J BIOL CHEM, V226, P497
[5] IS GLUCAGON A CHOLERETIC HORMONE AT PHYSIOLOGIC BLOOD-LEVELS
GARBEROGLIO, CA
BICKERSTAFF, KI
BAKER, AL
MOOSSA, AR
[J]. AMERICAN JOURNAL OF SURGERY, 1982, 143 (01) : 61 - 66
[6] PHARMACOLOGICAL AND PHYSIOLOGICAL DOSES OF INSULIN AND DETERMINANTS OF BILE-FLOW IN DOGS
GARBEROGLIO, CA
RICHTER, HM
HENAREJOS, A
MOOSSA, AR
BAKER, AL
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (01): : G157 - G163
[7] EFFECT OF GLUCAGON ON LIPIDS AND GLUCOSE IN NORMAL AND EVISCERATED RATS AND ON ISOLATED PERFUSED RAT LIVERS
GORMAN, CK
SALTER, JM
PENHOS, JC
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1967, 16 (12): : 1140 - &
[8] EFFECTS OF CHRONIC GLUCAGON ADMINISTRATION ON CHOLESTEROL AND BILE-ACID METABOLISM
GUETTET, C
MATHE, D
RIOTTOT, M
LUTTON, C
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 963 (02) : 215 - 223
[9] COMPARISON OF HEPATIC EXTRACTION OF INSULIN AND GLUCAGON IN CONSCIOUS AND ANESTHETIZED DOGS
ISHIDA, T
LEWIS, RM
HARTLEY, CJ
ENTMAN, ML
FIELD, JB
[J]. ENDOCRINOLOGY, 1983, 112 (03) : 1098 - 1109
[10] INSULINS EFFECT ON BILE-FLOW AND LIPID EXCRETION DURING EUGLYCEMIA AND HYPOGLYCEMIA
JONES, RS
PUTNAM, W
ANDERSEN, DK
HANKS, JB
LEBOVITZ, HE
[J]. DIGESTIVE DISEASES AND SCIENCES, 1984, 29 (01) : 33 - 39

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