EVALUATION OF PLANT-EXTRACTS FOR ANTILEISHMANIAL ACTIVITY USING A MECHANISM-BASED RADIORESPIROMETRIC MICROTECHNIQUE (RAM)

被引：28

作者：

IWU, MM ^{[1
]}

JACKSON, JE ^{[1
]}

TALLY, JD ^{[1
]}

KLAYMAN, DL ^{[1
]}

机构：

[1] WALTER REED ARMY INST RES, DEPT PARASITOL, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA

来源：

PLANTA MEDICA | 1992年 / 58卷 / 05期

关键词：

LEISHMANIASIS; GONGRONEMA-LATIFOLIA; DORSTENIA-MULTIRADIATA; PICRALIMA-NITIDA; DESMODIUM-GANGETICUM; COLA-ATTIENSIS;

D O I：

10.1055/s-2006-961508

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of (CO2)-C-14 from a battery of C-14-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 mug/ml or less against a visceral Leishmania isolate.

引用

页码：436 / 441

页数：6

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