INDUCTION OF INTERCALATED CELL CHANGES IN RAT PUPS FROM ACID-LOADED AND ALKALI-LOADED MOTHERS

被引:13
作者
NARBAITZ, R [1 ]
KAPAL, VK [1 ]
LEVINE, DZ [1 ]
机构
[1] UNIV OTTAWA,DEPT MED,OTTAWA K1H 8M5,ONTARIO,CANADA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 03期
关键词
KIDNEY INTERCALATED CELLS; PROTON PUMPS; ACIDOSIS; ALKALOSIS; RAT FETUSES;
D O I
10.1152/ajprenal.1993.264.3.F415
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We evaluated the effects of acid-base changes in pregnant and lactating dams on intercalated cell morphology and populations in newborn and 2-wk-old rats. Collecting ducts were studied with transmission electron microscopy with intercalated cells identified by the presence of 10-nm studs in the cytoplasmic face of apical membranes (A-type intercalated cells) or basolateral membranes (B-type intercalated cells). In newborn and 2-wk-old pups from dams with metabolic alkalosis, there was a significantly larger percentage of B-type intercalated cells and a smaller percentage of A-type intercalated cells. Acid loading with NH4Cl, however, did not produce an increase in the percentage of A-type intercalated cells, but reduced the percentage of B-type intercalated cells. We conclude that maternal metabolic alkalosis is associated with an increase in the percentage of B-type intercalated cells, suggesting that the initial differentiation of intercalated cells is responsive to maternal acid-base disturbances.
引用
收藏
页码:F415 / F420
页数:6
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