FURTHER-STUDIES OF 31 TEMPERATURE-SENSITIVE MUTANTS OF MOUSE CYTOMEGALOVIRUS - THERMAL-STABILITY, REPLICATION AND ANALYSIS OF TEMPERATURE-SENSITIVE FUNCTIONS BY TEMPERATURE SHIFT

被引：5

作者：

AKEL, HMO ^{[1
]}

FURARAH, AM ^{[1
]}

SWEET, C ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, SCH BIOL SCI, MICROBIAL MOLEC GENET & CELL BIOL RES GRP, BIRMINGHAM B15 2TT, ENGLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1993年 / 114卷 / 03期

关键词：

CYTOMEGALOVIRUS; MURINE; TS MUTANTS;

D O I：

10.1111/j.1574-6968.1993.tb06591.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A study of 31 temperature-sensitive mutants of mouse cytomegalovirus has indicated that two mutants (tsm1, tsm31) may be defective in immediate-early/early functions, two (tsm2, tsm3) may be defective in early functions and six (tsm9, tsml8, tsm22, tsm23, tsm28, tsm30) may be defective in early/late functions while the remainder are late function-defective mutants as determined by temperature-shift experiments. Three mutants (tsm1, tsm2, tsm3) were more thermostable than wild-type virus while three (tsm16, tsm26, tsm28) were more thermolabile; the remainder were similar in their thermostability to wild-type virus.

引用

页码：311 / 316

页数：6

共 8 条

[1] ISOLATION AND PRELIMINARY CHARACTERIZATION OF 25 TEMPERATURE-SENSITIVE MUTANTS OF MOUSE CYTOMEGALOVIRUS [J].