ROLES OF ZINC(II) ION IN ZINC ENZYMES

被引：67

作者：

KIMURA, E

机构：

[1] The Department of Medicinal Chemistry, School of Medicine, Hiroshima University, Minami-ku, Hiroshima, 734

来源：

PURE AND APPLIED CHEMISTRY | 1993年 / 65卷 / 03期

关键词：

D O I：

10.1351/pac199365030355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zinc(II) complexes of macrocyclic polyamines 1, 2 and 3 make good models for zinc enzyme (e.g., carbonic anhydrase, alcohol dehydrogenase, phosphatase) active centers. Intrinsic acid properties of Zn(II) pertinent to the biological functions are disclosed. Zinc(II) ion is not only important kinetically but it also plays an indispensable role thermodynamically.

引用

页码：355 / 359

页数：5

共 13 条

[1] ACID PROPERTIES OF ZINC(II) AND CADMIUM(II) IN COMPLEXATION WITH MACROCYCLIC OXO POLYAMINE LIGANDS
KIMURA, E
KOIKE, T
SHIOTA, T
IITAKA, Y
[J]. INORGANIC CHEMISTRY, 1990, 29 (23) : 4621 - 4629
[2] A TRIGONAL-BIPYRAMIDAL ZINC(II) COMPLEX OF A PHENOL-PENDANT MACROCYCLIC TRIAMINE
KIMURA, E
KOIKE, T
TORIUMI, K
[J]. INORGANIC CHEMISTRY, 1988, 27 (20) : 3687 - 3688
[3] A ZINC(II) COMPLEX OF 1,5,9-TRIAZACYCLODODECANE ([12]ANEN3) AS A MODEL FOR CARBONIC-ANHYDRASE
KIMURA, E
SHIOTA, T
KOIKE, T
SHIRO, M
KODAMA, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (15) : 5805 - 5811
[4] X-RAY STRUCTURAL STUDY OF A ZINC(II) INCLUSION COMPLEX OF A PHENOLATE-PENDANT CYCLAM
KIMURA, E
KUROSAKI, H
KOIKE, T
TORIUMI, K
[J]. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1992, 12 (1-4): : 377 - 387
[5] A VERSATILE MACROCYCLIC [12]ANEN3 FOR INTERCONVERSION OF TETRAHEDRAL AND TRIGONAL BIPYRAMIDAL ZINC(II) COMPLEXES - RELEVANCE TO 4-COORDINATE REVERSIBLE-ARROW 5-COORDINATE GEOMETRIES OF ZINC(II) IN CARBONIC-ANHYDRASE
KIMURA, E
KOIKE, T
SHIONOYA, M
SHIRO, M
[J]. CHEMISTRY LETTERS, 1992, (05) : 787 - 790
[6] SYNTHESIS AND METAL-COMPLEXES OF MACROCYCLIC TRIAMINES BEARING A PHENOL PENDANT
KIMURA, E
YAMAOKA, M
MORIOKA, M
KOIKE, T
[J]. INORGANIC CHEMISTRY, 1986, 25 (22) : 3883 - 3886
[7] SYNTHESIS, PROPERTIES, AND COMPLEXATION OF A NEW IMIDAZOLE-PENDANT MACROCYCLIC 12-MEMBERED TRIAMINE LIGAND
KIMURA, E
KUROGI, Y
SHIONOYA, M
SHIRO, M
[J]. INORGANIC CHEMISTRY, 1991, 30 (24) : 4524 - 4530
[8] KIMURA E, 1991, COMMENTS INORG CHEM, V11, P285
[9] KIMURA E, UNPUB
[10] KIMURA E, 1992, STUDIES ORGANIC CHEM, V45, P381

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