ACTIVITY OF HEPATIC DRUG-METABOLIZING-ENZYMES FOLLOWING OXAZEPAM-DOSED FEED TREATMENT IN B6C3F1 MICE

被引：16

作者：

GRIFFIN, RJ

BURKA, LT

CUNNINGHAM, ML

机构：

[1] Chemistry Branch, National Institute of Environmental Health Sciences MD C3-02, Research Triangle Park, NC 27709

来源：

TOXICOLOGY LETTERS | 1995年 / 76卷 / 03期

关键词：

OXAZEPAM; BENZODIAZEPINE; ENZYME INDUCTION; CYTOCHROME P450;

D O I：

10.1016/0378-4274(95)80010-B

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Oxazepam has been determined to be a potent hepatocarcinogen in mice. Evidence in the literature indicates that oxazepam is capable of inducing drug metabolizing enzymes in rodents and an association between enzyme induction and carcinogenesis has been proposed for other compounds such as phenobarbital. We examined the pattern of enzyme induction that occurs under bioassay conditions in male B6C3F1 mice. The results indicate that oxazepam is capable of inducing multiple drug metabolizing enzymes under bioassay conditions. Closer examination of the most induced samples suggests that oxazepam is a phenobarbital-type enzyme inducer.

引用

页码：251 / 256

页数：6

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