HYDROLYSIS OF AMIDES .3. DILUTE ACID HYDROLYSIS OF AMIDES OF TYPE R-CH2-CONH2

被引:21
作者
BOLTON, PD
JACKSON, GL
机构
[1] Department of Chemistry, Wollongong University College, Wollongong, NSW
关键词
D O I
10.1071/CH9690527
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Rate constants over a range of temperature, enthalpies of activation, and entropies of activation are reported for the dilute acid hydrolysis of n-valeramide, isovaleramide, 3,3-dimethylbutanamide, phenylacetamide, cyclohexylacetamide, methoxyacetamide, bromoacetamide, and chloroacetamide. The rate constants of the first six amides together with those of two other alkyl-substituted acetamides taken from a previous paper are almost perfectly correlated by the Taft linear steric energy relationship. The enthalpies of activation, also, show a linear dependence on the steric parameter, Es. The results obtained for the halogeno amides indicate that the acid hydrolysis of amides may show a slight sensitivity to polar effects. © 1969, CSIRO. All rights reserved.
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页码:527 / &
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