SISTER-CHROMATID EXCHANGES AND CHROMOSOMAL BREAKAGE IN PATIENTS TREATED WITH CYTOSTATICS

被引：92

作者：

MUSILOVA, J ^{[1
]}

MICHALOVA, K ^{[1
]}

URBAN, J ^{[1
]}

机构：

[1] INST SOCIAL MED & ORG HLTH SERV, PRAGUE, CZECHOSLOVAKIA

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 03期

关键词：

D O I：

10.1016/0165-1218(79)90023-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The frequency of structural chromosomal rearrangements and sister-chromatid exchanges (SCEs) was investigated in short-term phytohemagglutinin-stimulated lymphocyte cultures by means of bromodeoxyuridine substitution and fluorescence plus Giemsa (FPG) staining technique. Both these parameters were significantly increased in patients treated with comparatively low doses of cyclophosphamide, busulphan and adriamycin. The increased SCE rate was proportional to the number of chromosome breaks, the ratio of SCE to breaks being about 100:1. The increase in the SCE number was maintained for several months after the termination of cytostatic therapy, when the conventional analysis of chromosome breaks yielded normal results. Normal SCE values were obtained in two patients treated with low doses of fluorouracil. © 1979.

引用

页码：289 / 294

页数：6

共 11 条

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