STABILITY-INDICATING ASSAY FOR MECILLINAM USING HIGH-PRESSURE LIQUID-CHROMATOGRAPHY

被引：14

作者：

HAGEL, RB

WAYSEK, EH

HUMPHREY, D

机构：

[1] Quality Control Department, Hoffmann-La Roche Inc., Nutley, NJ 07110

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 170卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(00)95465-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-pressure liquid chromatographic method has been developed for use as a stability-indicating assay for mecillinam. Seven related compounds and at least one unknown degradation product are well separated and easily determined. The accuracy of the method is in good agreement with the published UV assay and the precision of a series of seven replicate determinations is ±1.0% R.S.D. © 1979.

引用

页码：391 / 398

页数：8

共 10 条

[1] HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC ANALYSIS OF PENICILLIN-G POTASSIUM AND ITS DEGRADATION PRODUCTS [J].