ANALYSIS OF FLUDROCORTISONE ACETATE AND ITS SOLID DOSAGE FORMS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：10

作者：

AST, TM ^{[1
]}

ABDOU, HM ^{[1
]}

机构：

[1] ER SQUIBB & SONS INC,NEW BRUNSWICK,NJ 08902

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Fludrocortisone acetate—and solid dosage forms; high‐performance liquid chromatographic analysis; High‐performance liquid chromatography—analysis; fludrocortisone acetate and solid dosage forms; Steroids—fludrocortisone acetate and solid dosage forms;

D O I：

10.1002/jps.2600680407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A newly developed reversed‐phase high‐performance liquid chromatographic assay and test method for determining content uniformity are described for fludrocortisone acetate. The method is stability indicating and separates most known degradation products and impurities. In addition, the method is simple, sensitive, accurate, and relatively free of interferences. The coefficient of variation for multiple weight assays is between 0.3 and 1.8%. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：421 / 423

页数：3