CYTOPLASMIC ORIGIN OF VARIABILITY IN THE TIMING OF S-PHASE IN MAMMALIAN-CELLS

被引：14

作者：

BROOKS, RF

机构：

[1] Cell Proliferation Laboratory Imperial Cancer Research Fund Lincoln's Inn Fields, London

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1979年 / 3卷 / 09期

关键词：

D O I：

10.1016/0309-1651(79)90075-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The time at which S phase begins in mammalian cells is highly variable with respect to cell age. Evidence is presented that this variability does not arise because the initiation of DNA synthesis depends on the stochastic interaction of an initiator substance with a rare initiation site. Instead, the signal responsible for starting S phase must appear at random in the cytoplasm and may be transient. © 1979.

引用

页码：707 / 716

页数：10

共 28 条

[1] CONTINUOUS PROTEIN-SYNTHESIS IS REQUIRED TO MAINTAIN PROBABILITY OF ENTRY INTO S-PHASE [J].

BROOKS, RF .

CELL, 1977, 12 (01) :311-317

[2] 3' DEOXYCYTIDINE, LIKE HYDROXYUREA, INHIBITS DNA-SYNTHESIS WITHOUT PREVENTING INITIATION OF CELL-CYCLE [J].

BROOKS, RF .

CELL BIOLOGY INTERNATIONAL REPORTS, 1978, 2 (03) :279-291

[3] KINETICS OF SERUM-INDUCED INITIATION OF DNA-SYNTHESIS IN BHK 21 C13 CELLS, AND INFLUENCE OF EXOGENOUS ADENOSINE [J].

BROOKS, RF .

JOURNAL OF CELLULAR PHYSIOLOGY, 1975, 86 (02) :369-378

[4] REGULATION OF FIBROBLAST CELL-CYCLE BY SERUM [J].

BROOKS, RF .

NATURE, 1976, 260 (5548) :248-250

[5] AUTORADIOGRAPHY OF HELA CELL DNA [J].

CAIRNS, J .

JOURNAL OF MOLECULAR BIOLOGY, 1966, 15 (01) :372-&

[6] EFFECTS OF CYTOCHALASINS ON MAMMALIAN CELLS [J].

CARTER, SB .

NATURE, 1967, 213 (5073) :261-&

[7] PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES [J].

DULBECCO, R ;

VOGT, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1954, 99 (02) :167-182

[8]

FOSTER DO, 1969, J BIOL CHEM, V244, P2675

[9] CELL-CYCLE STUDIES OF MONONUCLEATE AND CYTOCHALASIN-B-INDUCED BINUCLEATE FIBROBLASTS [J].

FOURNIER, RE ;

PARDEE, AB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) :869-873

[10]

GRAVES MJA, 1972, EXPTL CELL RES, V72, P393

← 1 2 3 →