FORMATION AND ACTION OF PROSTACYCLIN IN THE ISOLATED HUMAN UMBILICAL ARTERY

被引：15

作者：

HAMBERG, M ^{[1
]}

TUVEMO, T ^{[1
]}

SVENSSON, J ^{[1
]}

JONSSON, CE ^{[1
]}

机构：

[1] UNIV UMEA HOSP,DEPT PAEDIAT,S-90185 UMEA,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1979年 / 106卷 / 03期

关键词：

biosynthesis; human; in vitro; newborn; prostacyclin; prostaglandin; Umbilical artery;

D O I：

10.1111/j.1748-1716.1979.tb06400.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The transformation of [l‐14C]arachidonic acid by homogenates of human umbilical arteries was studied. The major compund formed was the stable end product of PGI2, i.e. 6‐keto‐PGF1α (lactol form) as analyzed by gas‐liquid chromatography‐mass spectrometry. PGI2 was generated by incubating PGH2 with a lyophilized pig aorta microsome preparation. PGI2 concentrations around 10 ng/ml relaxed the human umbilical artery preparation significantly. Formation of PGI2 by umbilical arteries during pregnancy might be a mechanism for regulation of blood flow to the fetus. © 1979 Scandinavian Physiological Society

引用

页码：289 / 292

页数：4

共 12 条

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