MOLECULAR MECHANISMS UNDERLYING LYMPHOCYTE RECIRCULATION .2. DIFFERENTIAL REGULATION OF LFA-1 IN THE INTERACTION BETWEEN LYMPHOCYTES AND HIGH ENDOTHELIAL-CELLS

被引:61
作者
TAMATANI, T [1 ]
KOTANI, M [1 ]
TANAKA, T [1 ]
MIYASAKA, M [1 ]
机构
[1] TOKYO METROPOLITAN INST MED SCI, DEPT IMMUNOL, 3-18-22 HON KOMAGOME, BUNKYO KU, TOKYO 113, JAPAN
关键词
D O I
10.1002/eji.1830210351
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although it has been suggested that LFA-1 is one of the important molecules mediating interaction between lymphocytes and high endothelial (HE) cells, the implication was based on the observation that lymphocyte binding to high endothelial venules in frozen lymph node sections was partially inhibited by anti-LFA-1 monoclonal antibody at 4-degrees-C. However, it has previously been unequivocally demonstrated that LFA-1 molecule is unable to function at this low temperature. To assess the actual involvement of LFA-1 in lymphocyte-HE cell interaction at body temperature, we examined effects of newly developed anti-rat LFA-1 and anti-rat ICAM-1 monoclonal antibody on binding of resting or activated lymphocytes to a rat HE cell line at 37-degrees-C. We found that (a) LFA-1/ICAM-1-independent pathway was predominant in the interaction between resting lymphocytes and HE cells, indicating that LFA-1 functions little, if any, in the interaction and (b) lymphocyte triggering through CD3 significantly increased binding inducing a LFA-1/ICAM-1-dependent pathway, whereas phorbol 12-myristate 13-acetate stimulation also enhanced lymphocyte binding but inducing a LFA-1-dependent/ICAM-1-independent pathway. In both cases no apparent alteration in LFA-1 expression was observed, suggesting that the increase in lymphocyte adhesion was not due to a quantitative but a qualitative change induced in LFA-1 molecule upon lymphocyte stimulation. These findings suggest that LFA-1 is normally inert but can be "switched" upon lymphocyte stimulation to participate in lymphocyte-HE cell interaction, and that the LFA-1's ligand specificity can be differentially regulated at the lymphocyte-HE venule interface.
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页码:855 / 858
页数:4
相关论文
共 25 条
[1]   ACTIVATION OF LYMPHOCYTES-T VIA MONOCLONAL-ANTIBODIES AGAINST RAT-CELL SURFACE-ANTIGENS WITH PARTICULAR REFERENCE TO CD2 ANTIGEN [J].
BEYERS, AD ;
BARCLAY, AN ;
LAW, DA ;
HE, Q ;
WILLIAMS, AF .
IMMUNOLOGICAL REVIEWS, 1989, 111 :59-77
[2]  
DANA N, 1986, J IMMUNOL, V137, P3259
[3]  
DIMINNO G, 1983, BLOOD, V61, P140
[4]  
DUSTIN ML, 1986, J IMMUNOL, V137, P245
[5]   T-CELL RECEPTOR CROSS-LINKING TRANSIENTLY STIMULATES ADHESIVENESS THROUGH LFA-1 [J].
DUSTIN, ML ;
SPRINGER, TA .
NATURE, 1989, 341 (6243) :619-624
[6]   ENDOTHELIAL INTERLEUKIN-8 - A NOVEL INHIBITOR OF LEUKOCYTE-ENDOTHELIAL INTERACTIONS [J].
GIMBRONE, MA ;
OBIN, MS ;
BROCK, AF ;
LUIS, EA ;
HASS, PE ;
HEBERT, CA ;
YIP, YK ;
LEUNG, DW ;
LOWE, DG ;
KOHR, WJ ;
DARBONNE, WC ;
BECHTOL, KB ;
BAKER, JB .
SCIENCE, 1989, 246 (4937) :1601-1603
[7]   ROUTE OF RE-CIRCULATION OF LYMPHOCYTES IN RAT [J].
GOWANS, JL ;
KNIGHT, EJ .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 159 (975) :257-+
[8]  
HAMANN A, 1988, J IMMUNOL, V140, P693
[9]   MOLECULAR MECHANISMS UNDERLYING LYMPHOCYTE RECIRCULATION .1. FUNCTIONAL, PHENOTYPICAL AND MORPHOLOGICAL CHARACTERIZATION OF HIGH ENDOTHELIAL-CELLS CULTURED INVITRO [J].
ISE, Y ;
YAMAGUCHI, K ;
SATO, K ;
YAMAMURA, Y ;
KITAMURA, F ;
TAMATANI, T ;
MIYASAKA, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (08) :1235-1244
[10]   PURIFIED INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IS A LIGAND FOR LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) [J].
MARLIN, SD ;
SPRINGER, TA .
CELL, 1987, 51 (05) :813-819