HISTAMINE CONCENTRATION OF GASTRIC-MUCOSA IN HELICOBACTER-PYLORI POSITIVE AND NEGATIVE CHILDREN

被引:30
作者
QUEIROZ, DMM
MENDES, EN
ROCHA, GA
BARBOSA, AJA
CARVALHO, AST
CUNHAMELO, JR
机构
[1] UNIV FED MINAS GERAIS,FAC MED,DEPT PEDIAT,BR-30130 BELO HORIZONTE,MG,BRAZIL
[2] UNIV FED MINAS GERAIS,FAC MED,DEPT PEDIAT,BR-30130 BELO HORIZONTE,MG,BRAZIL
关键词
D O I
10.1136/gut.32.5.464
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The histamine concentration was determined by enzymatic isotopic method in biopsy specimens of oxyntic mucosa from 37 children. Nineteen of the 37 had Helicobacter pylori associated gastritis (9 with duodenal ulcer). The histamine concentration in the H pylori negative group was mean (SD) 54.1 (23.1)-mu-g/g fresh weight, and that in the H pylori positive group was 26.3 (14.2)-mu-g/g (p < 0.01). There was also a significant difference between H pylori positive patients with duodenal ulcer (19.8 (6.3) mu-g/g) and those without ulcer (31.4 (17.9)-mu-g/g) (p < 0.05). These results suggest that H pylori positive patients, especially those with duodenal ulcer, have reduced 'stored' histamine, perhaps because of increased histamine liberation.
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页码:464 / 466
页数:3
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