ALPHA-CHYMOTRYPSIN CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF ALKENYL-ALPHA-AMINO ACID-ESTERS

被引：16

作者：

SCHRICKER, B

THIRRING, K

BERNER, H

机构：

[1] Sandoz Forschungsinstitut, A-1235 Wien

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80152-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Preparative scale hydrolyses (0.1-0.3 M) were carried out on a series of alkenyl-alpha-aminoacid esters catalyzed by different hydrolytic enzymes. Within the scope of investigated substrates (1-10) and enzymes (PLE, chymopapain, papain, chymotrypsin, trypsin) alpha-chymotrypsin was shown to be the most effective. It showed broad substrate specificity, high stereoselectivity (ee 86-96%) and gave high chemical yields (up to 99%).

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页码：387 / 390

页数：4

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