DETERMINATION OF PARTS-PER-MILLION LEVELS OF TRIFLUOROACETIC-ACID IN CERONAPRIL BULK SUBSTANCE BY HEADSPACE CAPILLARY GAS-CHROMATOGRAPHY

被引：7

作者：

BOTH, DA

JEMAL, M

机构：

[1] Bristol-Myers Squibb Company, Bristol-Myers Squibb, Pharmaceutical Research Institute, New Brunswick, NJ 08903-0191

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 596卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)80206-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A headspace capillary gas chromatographic method was developed to determine trifluoroacetic acid (TFA) in a bulk substance (ceronapril). The bulk sample is reacted in a sealed headspace vial with dimethyl sulfate in concentrated sulfuric acid to convert TFA to methyl trifluoroacetate (MTFA). A portion of the headspace of the vial containing the MTFA is chromatographed on a PoraPLOT Q 0.32 mm I.D. capillary column in the split injection mode with flame ionization detection. The limit of detection is less than 10 ppm (w/w).

引用

页码：85 / 90

页数：6

共 7 条

[1] GAS-CHROMATOGRAPHIC DETERMINATION OF CHLORAL HYDRATE, TRICHLOROETHANOL AND TRICHLOROACETIC-ACID IN BLOOD AND IN URINE EMPLOYING HEAD-SPACE ANALYSIS [J].

BREIMER, DD ;

KETELAARS, HC ;

VANROSSU.JM .

JOURNAL OF CHROMATOGRAPHY, 1974, 88 (01) :55-63

[2] CERANAPRIL (SQ-29,852), AN ORALLY ACTIVE INHIBITOR OF ANGIOTENSIN CONVERTING ENZYME (ACE) [J].

DEFORREST, JM ;

WALDRON, TL ;

HARVEY, C ;

SCALESE, R ;

HAMMERSTONE, S ;

POWELL, JR ;

KARANEWSKY, D .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 16 (01) :121-127

[3]

GRUNDY J, 1972, TETRAHEDRON LETT, P757

[4] EFFECT OF SQ29,852, A NEW ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR WITH A PHOSPHONIC ACID GROUP, ON THE ACTIVITY OF ANGIOTENSIN CONVERTING ENZYME FROM HUMAN KIDNEY [J].

HIWADA, K ;

INOUE, Y ;

KOKUBU, T .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1990, 21 (04) :555-558

[5] (PHOSPHINYLOXY)ACYL AMINO-ACID INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME (ACE) .1. DISCOVERY OF (S)-1-[6-AMINO-2-[[HYDROXY(4-PHENYLBUTYL)PHOSPHINYL]OXY]-1-OXOHEXYL]-L-PROLINE, A NOVEL ORALLY ACTIVE INHIBITOR OF ACE [J].

KARANEWSKY, DS ;

BADIA, MC ;

CUSHMAN, DW ;

DEFORREST, JM ;

DEJNEKA, T ;

LOOTS, MJ ;

PERRI, MG ;

PETRILLO, EW ;

POWELL, JR .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (01) :204-212

[6] GAS-CHROMATOGRAPHIC METHOD FOR THE HALOTHANE METABOLITES, TRIFLUOROACETIC-ACID AND BROMIDE, IN BIOLOGICAL-FLUIDS [J].

MAIORINO, RM ;

GANDOLFI, AJ ;

SIPES, IG .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1980, 4 (05) :250-254

[7]

TRIEBIG G, 1980, APPLIED HEADSPACE GA, P133

← 1 →