GLYCYLGLUTAMINE - METABOLISM AND EFFECTS ON ORGAN BALANCES OF AMINO-ACIDS IN POSTABSORPTIVE AND STARVED SUBJECTS

被引:22
作者
LOCHS, H
HUBL, W
GASIC, S
ROTH, E
MORSE, EL
ADIBI, SA
机构
[1] UNIV VIENNA, GASTROENTEROL & HEPATOL CLIN 1, WAHRINGER GURTEL 18-20, A-1090 VIENNA, AUSTRIA
[2] UNIV VIENNA, SURG CLIN 1, A-1090 VIENNA, AUSTRIA
[3] UNIV VIENNA, MED CLIN 1, A-1090 VIENNA, AUSTRIA
[4] UNIV PITTSBURGH, MONTEFIORE HOSP, CLIN NUTR UNIT, PITTSBURGH, PA 15213 USA
[5] UNIV PITTSBURGH, SCH MED, DEPT MED, PITTSBURGH, PA 15213 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 02期
关键词
AMINO ACID METABOLISM; PEPTIDES; GLUCONEOGENESIS; AMMONIAGENESIS;
D O I
10.1152/ajpendo.1992.262.2.E155
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The present study was designed to investigate the metabolism of glycylglutamine and its effects on organ balances of amino acids during intravenous infusion of this dipeptide (100-mu-mol.h-1.kg-1) in postabsorptive and briefly starved (84-86 h) human subjects. Arterial concentrations of glycylglutamine were not significantly different in postabsorptive (265 +/- 18-mu-M) and starved (241 +/- 13-mu-M) subjects. Among the organs examined, kidney predominated in clearance of glycylglutamine from plasma. Moreover, renal clearance of glycylglutamine was reduced by starvation (87 +/- 7 vs. 52 +/- 5-mu-mol/min, P < 0.01), whereas neither splanchnic nor muscle clearance was significantly affected. Infusion of glycylglutamine raised plasma concentrations of glycine and glutamine by increasing renal release of these amino acids. In postabsorptive subjects the infusion significantly increased splanchnic balances of glycine and glutamine with little or no effect on the muscle balances; the opposite was found in starved subjects. As far as other amino acids are concerned, the infusion decreased the muscle release of alanine and increased renal release of serine. We conclude that the amino acid residues of glycylglutamine are largely metabolized by the splanchnic organs in postabsorptive subjects and by peripheral organs in starved subjects. The latter results in selective inhibition of muscle release of amino acids.
引用
收藏
页码:E155 / E160
页数:6
相关论文
共 25 条
  • [1] POSSIBLE SOURCES OF GLUTAMINE FOR PARENTERAL-NUTRITION - IMPACT ON GLUTAMINE-METABOLISM
    ABUMRAD, NN
    MORSE, EL
    LOCHS, H
    WILLIAMS, PE
    ADIBI, SA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02): : E228 - E234
  • [2] INTRAVENOUS USE OF GLUTAMINE IN PEPTIDE FORM - CLINICAL-APPLICATIONS OF OLD AND NEW OBSERVATIONS
    ADIBI, SA
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (08): : 89 - 92
  • [3] METABOLISM OF INTRAVENOUSLY ADMINISTERED DIPEPTIDES IN RATS - EFFECTS ON AMINO-ACID POOLS, GLUCOSE CONCENTRATION AND INSULIN AND GLUCAGON-SECRETION
    ADIBI, SA
    KRZYSIK, BA
    DRASH, AL
    [J]. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1977, 52 (02): : 193 - 204
  • [4] Bergmeyer HI., 1974, METHODS ENZYMATIC AN
  • [5] THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN
    BRADLEY, SE
    INGELFINGER, FJ
    BRADLEY, GP
    CURRY, JJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1945, 24 (06) : 890 - 897
  • [6] BRUN C, 1951, J LAB CLIN MED, V37, P955
  • [7] Cahill G F Jr, 1970, N Engl J Med, V282, P668, DOI 10.1056/NEJM197003052821026
  • [8] CHIASSON JL, 1979, DIABETES, V28, P56
  • [9] ERIKSSON LS, 1988, METABOLISM, V37, P1159
  • [10] AMINO ACID METABOLISM DURING PROLONGED STARVATION
    FELIG, P
    OWEN, OE
    WAHREN, J
    CAHILL, GF
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1969, 48 (03) : 584 - &