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THE UDP-GALACTOSE TRANSLOCATOR GENE IS MAPPED TO BAND-XP11.23-P11.22 CONTAINING THE WISKOTT-ALDRICH SYNDROME LOCUS

被引：16
作者：
HARA, T
YAMAUCHI, M
TAKAHASHI, E
HOSHINO, M
AOKI, K
AYUSAWA, D
KAWAKITA, M
机构：
[1] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN
[2] NATL INST RADIOL SCI,DIV GENET,CHIBA 260,JAPAN
[3] UNIV TOKYO,COLL ARTS & SCI,DEPT PURE & APPL SCI,MEGURO KU,TOKYO 153,JAPAN
来源：
SOMATIC CELL AND MOLECULAR GENETICS | 1993年 / 19卷 / 06期
关键词：
D O I：
10.1007/BF01233383
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescent in situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS).
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页码：571 / 575
页数：5
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