8-CHLORODIBENZ[B,F][1,4]OXAZEPINE-10(11H)-CARBOXYLIC ACID, 2-[3-[2-(FURANYLMETHYL)THIO]-1-OXOPROPYL]HYDRAZIDE (SC-51322) - A POTENT PGE(2) ANTAGONIST AND ANALGESIC

被引：57

作者：

HALLINAN, EA

STAPELFELD, A

SAVAGE, MA

REICHMAN, M

机构：

[1] Department of Chemistry Searle, Skokie, IL 60077

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期

关键词：

D O I：

10.1016/0960-894X(94)80027-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SC-51322 is the most potent PGE(2) antagonist (pA(2) = 8.1) and analgesic (ED(50) = 0.9 mg/kg) that has been seen in this series of N-substituted dibenzoxazepines.

引用

页码：509 / 514

页数：6

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