DIETARY PROTEIN-INDUCED RENAL GROWTH - CORRELATION BETWEEN RENAL IGF-I SYNTHESIS AND HYPERPLASIA

被引:30
作者
CHIN, E
BONDY, CA
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 266卷 / 04期
关键词
THICK ASCENDING LIMB; MESSENGER RIBONUCLEIC ACID; HYPERTROPHY; HYPERPLASIA; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; DEOXYRIBONUCLEIC ACID SYNTHESIS; OSMOTIC LOAD; NEPHRON;
D O I
10.1152/ajpcell.1994.266.4.C1037
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Insulin-like growth factor I (IGF-I) and IGF binding protein 1 (IGFBP-1) mRNAs are colocalized in the medullary thick ascending limb (MTAL) of the rat nephron, a segment that undergoes selective growth in response to elevated dietary protein. In the present study, rats were fed isocaloric diets containing variable protein content (6-40%) for 1-7 days, and changes in fractional renal weight, MTAL length, and regional DNA synthesis were assayed and compared with local changes in IGF-I/IGFBP-1 mRNAs, as determined by quantitative in situ hybridization. Rats switched to high-protein diets demonstrated increased IGF-I and decreased IGFBP-1 mRNA levels in MTALs, whereas those switched to low protein showed inverse changes. The increase in renal IGF-I mRNA was maximal at 2 days and was closely paralleled by significant increases in fractional renal weight, DNA synthesis, and MTAL length. Similar changes were seen in vasopressin-deficient Brattleboro and growth hormone (GH)deficient dwarf rats in response to high-protein diets, suggesting that the effects of dietary protein in this model are not mediated by vasopressin or GH. The close spatial and temporal correlation between changes in renal IGF-I expression and changes in regional growth parameters strongly supports a role for locally produced IGF-I in the induction of protein-induced renal growth.
引用
收藏
页码:C1037 / C1045
页数:9
相关论文
共 43 条
[1]   INSULIN-LIKE GROWTH-FACTORS AND DIABETES [J].
BACH, LA ;
RECHLER, MM .
DIABETES-METABOLISM REVIEWS, 1992, 8 (03) :229-257
[2]  
BOUBY N, 1987, KIDNEY INT, V32, pS57
[3]   ROLE OF THE URINARY CONCENTRATING PROCESS IN THE RENAL EFFECTS OF HIGH PROTEIN-INTAKE [J].
BOUBY, N ;
TRINHTRANGTAN, MM ;
LAOUARI, D ;
KLEINKNECHT, C ;
GRUNFELD, JP ;
KRIZ, W ;
BANKIR, L ;
DOUTE, M ;
HAHNEL, B ;
COUTAUD, C .
KIDNEY INTERNATIONAL, 1988, 34 (01) :4-12
[4]   SELECTIVE ADH-INDUCED HYPERTROPHY OF THE MEDULLARY THICK ASCENDING LIMB IN BRATTLEBORO RATS [J].
BOUBY, N ;
BANKIR, L ;
TRINHTRANGTAN, MM ;
MINUTH, WW ;
KRIZ, W .
KIDNEY INTERNATIONAL, 1985, 28 (03) :456-466
[5]   EFFECT OF HIGH PROTEIN-INTAKE ON SODIUM, POTASSIUM-DEPENDENT ADENOSINE-TRIPHOSPHATASE ACTIVITY IN THE THICK ASCENDING LIMB OF HENLE LOOP IN THE RAT [J].
BOUBY, N ;
BANKIR, L .
CLINICAL SCIENCE, 1988, 74 (03) :319-329
[6]   FUNCTIONAL-RESPONSE OF HEALTHY AND DISEASED GLOMERULI TO A LARGE, PROTEIN-RICH MEAL [J].
CHAN, AYM ;
CHENG, MLL ;
KEIL, LC ;
MYERS, BD .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (01) :245-254
[7]   GROWTH HORMONE-DEFICIENT DWARFISM IN THE RAT - A NEW MUTATION [J].
CHARLTON, HM ;
CLARK, RG ;
ROBINSON, ICAF ;
GOFF, AEP ;
COX, BS ;
BUGNON, C ;
BLOCH, BA .
JOURNAL OF ENDOCRINOLOGY, 1988, 119 (01) :51-&
[8]   ANATOMICAL RELATIONSHIPS IN THE PATTERNS OF INSULIN-LIKE GROWTH-FACTOR (IGF)-I, IGF BINDING PROTEIN-1, AND IGF-I RECEPTOR GENE-EXPRESSION IN THE RAT-KIDNEY [J].
CHIN, E ;
ZHOU, J ;
BONDY, C .
ENDOCRINOLOGY, 1992, 130 (06) :3237-3245
[9]   PARTITION OF INSULIN-LIKE GROWTH-FACTOR (IGF)-BINDING SITES BETWEEN THE IGF-I AND IGF-II RECEPTORS AND IGF-BINDING PROTEINS IN THE HUMAN KIDNEY [J].
CHIN, E ;
MICHELS, K ;
BONDY, CA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (01) :156-164
[10]   INSULIN-LIKE GROWTH-FACTOR SYSTEM GENE-EXPRESSION IN THE HUMAN KIDNEY [J].
CHIN, E ;
BONDY, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (03) :962-968