CARBOPLATIN, METHOTREXATE, AND VINBLASTINE IN OUTPATIENTS WITH ADVANCED TRANSITIONAL-CELL CARCINOMA OF THE BLADDER

被引：5

作者：

PRONZATO, P ^{[1
]}

LANDUCCI, M ^{[1
]}

VAIRA, F ^{[1
]}

VIGANI, A ^{[1
]}

BERTELLI, G ^{[1
]}

机构：

[1] IST NAZL RIC CANC,MED ONCOL SERV,I-16132 GENOA,ITALY

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1995年 / 18卷 / 03期

关键词：

TRANSITIONAL CELL CARCINOMA; BLADDER CANCER; CARBOPLATIN; METHOTREXATE; VINBLASTINE; (CAMV); COMBINATION;

D O I：

10.1097/00000421-199506000-00008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty outpatients with locally advanced (inoperable) or metastatic transitional cell carcinomas of the bladder were treated with carboplatin (300 mg/m(2) i,v., day 1) + methotrexate (40 mg/m(2) days 1 and 8) + vinblastine (6 mg/m(2) days 1 and 8) (CaMV), every 4 weeks, One patient died of disease progression before completing at least 2 cycles of chemotherapy. Seven patients (35%) obtained a partial response; 8 had disease stabilization (40%) and 4 progressed (20%). Median duration of response was 3 months (range: 3-9), and median overall survival was 12+ months (range: 1-18+). None of the patients suffered grade IV toxicities, and no nephro-, neuro-, or ototoxicity was observed.

引用

页码：223 / 225

页数：3

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