MUTAGENICITY OF VINYL-CHLORIDE, VINYLIDENE-CHLORIDE AND CHLOROPRENE IN V79 CHINESE-HAMSTER CELLS

被引：27

作者：

DREVON, C ^{[1
]}

KUROKI, T ^{[1
]}

机构：

[1] INT AGCY RES CANC, CHEM CARCINOGENESIS UNIT, F-69008 LYON, FRANCE

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 02期

关键词：

D O I：

10.1016/0165-1218(79)90129-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenicity of vinyl chloride, vinylidene chloride (1,1-dichloroethylene) and chloroprene (2-chloro-1,3-butadiene) [industrial chemicals] was tested in V79 Chinese hamster cells in the presence of a 15,000 .times. g liver supernatant from phenobarbitone-pretreated rats and mice. Mutations in terms of 8-azaguanine and ouabain resistance were induced in a dose-related fashion by exposure to vapor of vinyl chlordie in the presence of liver supernatant from phenobarbitone-pretreated rats. Vapors of vinylidene chloride and chloroprene induced a dose-related toxicity in the presence of liver supernatant from phenobarbitone-pretreated rats, but these 2 compounds were not mutagenic in V79 Chinese hamster cells under these conditions. The metabolic activation of these compounds and the correlation between their mutagenicity and carcinogenicity in humans and experimental animals were discussed.

引用

页码：173 / 182

页数：10

共 31 条

[1] COMPARISON OF MUTAGENIC PROPERTIES OF VINYL-CHLORIDE AND METHYL-CHLORIDE [J].

ANDREWS, AW ;

ZAWISTOWSKI, ES ;

VALENTINE, CR .

MUTATION RESEARCH, 1976, 40 (03) :273-275

[2] LIVER-MICROSOME-MEDIATED FORMATION OF ALKYLATING-AGENTS FROM VINYL BROMIDE AND VINYL-CHLORIDE [J].

BARBIN, A ;

BRESIL, H ;

CROISY, A ;

JACQUIGNON, P ;

MALAVEILLE, C ;

MONTESANO, R ;

BARTSCH, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 67 (02) :596-603

[3] HUMAN, RAT AND MOUSE LIVER-MEDIATED MUTAGENICITY OF VINYL-CHLORIDE IN S-TYPHIMURIUM STRAINS [J].

BARTSCH, H ;

MALAVEILLE, C ;

MONTESANO, R .

INTERNATIONAL JOURNAL OF CANCER, 1975, 15 (03) :429-437

[4] MUTAGENIC AND CARCINOGENIC EFFECTS OF VINYL-CHLORIDE [J].

BARTSCH, H ;

MONTESANO, R .

MUTATION RESEARCH, 1975, 32 (02) :93-113

[5] TISSUE-MEDIATED MUTAGENICITY OF VINYLIDENE CHLORIDE AND 2-CHLOROBUTADIENE IN SALMONELLA-TYPHIMURIUM [J].

BARTSCH, H ;

MALAVEILLE, C ;

MONTESANO, R ;

TOMATIS, L .

NATURE, 1975, 255 (5510) :641-643

[6] ABSENCE OF MUTAGENICITY OF PRAZIQUANTEL, A NEW, EFFECTIVE, ANTI-SCHISTOSOMAL DRUG, IN BACTERIA, YEASTS, INSECTS AND MAMMALIAN-CELLS [J].

BARTSCH, H ;

KUROKI, T ;

MALAVEILLE, C ;

LOPRIENO, N ;

BARALE, R ;

ABBONDANDOLO, A ;

BONATTI, S ;

RAINALDI, G ;

VOGEL, E ;

DAVIS, A .

MUTATION RESEARCH, 1978, 58 (2-3) :133-142

[7] MUTAGENICITY AND METABOLISM OF VINYL-CHLORIDE AND RELATED COMPOUNDS [J].

BARTSCH, H ;

MALAVEILLE, C ;

BARBIN, A ;

BRESIL, H ;

TOMATIS, L ;

MONTESANO, R .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1976, 17 (OCT) :193-198

[8]

DREVON C, 1977, PROGR GENETIC TOXICO, P207

[9] INDUSTRIAL MUTAGENS AND POTENTIAL MUTAGENS .1. HALOGENATED ALIPHATIC DERIVATIVES [J].

FISHBEIN, L .

MUTATION RESEARCH, 1976, 32 (3-4) :267-307

[10] VINYL-CHLORIDE DEPENDENT MUTAGENSIS - EFFECTS OF LIVER EXTRACTS AND FREE-RADICALS [J].

GARRO, AJ ;

GUTTENPLAN, JB ;

MILVY, P .

MUTATION RESEARCH, 1976, 38 (02) :81-88

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