A NEW FAMILY OF 5-CARBON IMINOALDITOLS WHICH ARE POTENT GLYCOSIDASE INHIBITORS

被引:79
作者
BERNOTAS, RC [1 ]
PAPANDREOU, G [1 ]
URBACH, J [1 ]
GANEM, B [1 ]
机构
[1] CORNELL UNIV,DEPT CHEM,BAKER LAB,ITHACA,NY 14853
关键词
D O I
10.1016/S0040-4039(00)97405-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of 1,5-dideoxy-1,5-imino-D-xylitol 2 (and the enantiomeric iminoalditols 3 and 4) is described. Alditol 2 compares favorably with 1-deoxynojirimycin 1 as a potent inhibitor of β-glucosidase. © 1990.
引用
收藏
页码:3393 / 3396
页数:4
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