STRUCTURE OF THE HUMAN FETAL GLOBIN GENE LOCUS

被引：104

作者：

LITTLE, PFR ^{[1
]}

FLAVELL, RA ^{[1
]}

KOOTER, JM ^{[1
]}

ANNISON, G ^{[1
]}

WILLIAMSON, R ^{[1
]}

机构：

[1] UNIV AMSTERDAM,MED ENZYMOL & MOLEC BIOL SECT,BIOCHEM LAB,NL-1005 GA AMSTERDAM,NETHERLANDS

来源：

NATURE | 1979年 / 278卷 / 5701期

关键词：

D O I：

10.1038/278227a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have derived a 'map' of restriction enzyme sites in and around the human γ-globin genes. This has enabled us to show that there are two γ-globin genes per haploid set, that the genes contain 'introns' within the same regions of DNA as the human β and δ-globin genes, and that the genes are 3,500 base pairs apart. We conclude that the correct gene organisation of the human β-like globin locus is Gγ Aγδβ. © 1979 Nature Publishing Group.

引用

页码：227 / 231

页数：5

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