EFFECT OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR ON SURVIVAL IN LETHALLY IRRADIATED MICE

被引：25

作者：

HOSOI, Y

KURISHITA, A

ONO, T

SAKAMOTO, K

机构：

[1] Departments of Radiation Research and Radiology, Tohoku University School of Medicine, Sendai

来源：

ACTA ONCOLOGICA | 1992年 / 31卷 / 01期

关键词：

RADIATION; TOTAL BODY; MICE; GRANULOCYTE; COLONY-STIMULATING FACTOR (G-CSF); SURVIVAL;

D O I：

10.3109/02841869209088267

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Repeated injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5-mu-g/mouse of rhG-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhG-CSF increased the number of blood-circulating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhG-CSF treatment compared with the values for mice irradiated only.

引用

页码：59 / 63

页数：5

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