INCREASED SEROTONIN PLATELET UPTAKE AFTER TIANEPTINE ADMINISTRATION IN DEPRESSED-PATIENTS

被引:32
作者
CHAMBA, G
LEMOINE, P
FLACHAIRE, E
FERRY, N
QUINCY, C
SASSARD, J
FERBER, C
MOCAER, E
KAMOUN, A
RENAUD, B
机构
[1] HOP VINATIER,UNITE CLIN PSYCHIAT BIOL,BRON,FRANCE
[2] FAC PHARM LYON,CNRS,UMR 105,LYONS,FRANCE
[3] INST RECH INT SERVIER,NEUILLY SUR SEINE,FRANCE
[4] FAC PHARM LYON,CNRS,URA 606,LYONS,FRANCE
[5] UNIV LYON 1,DEPT PHYSIOL & PHARMACOL CLIN,F-69365 LYONS 2,FRANCE
[6] HOP NEUROL,SERV BIOL,F-69394 LYONS 3,FRANCE
关键词
D O I
10.1016/0006-3223(91)90030-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tianeptine is a new antidepressant drug reported to enhance serotonin (5-hydroxytryptamine [5-HT]) uptake in rat brain. The effect of tianeptine on 5-HT platelet uptake was studied in 10 depressed patients treated for 28 days. Tianeptine increases V(max) of 5-HT platelet uptake during treatment without inducing any change in K(m). As early as 2 hr after the first administration, V(max) increased significantly (+23%, alpha = 0.01). Although of a lesser magnitude, 5-HT platelet uptake remains increased after chronic administration (+14% on day 10 and +13% on day 28). This suggests that tianeptine affects 5-HT platelet uptake sites, either directly or via an action on modulators of 5-HT uptake. These results, in contrast with the action of other tricyclic antidepressants, confirm the original action of tianeptine on 5-HT platelet metabolism.
引用
收藏
页码:609 / 617
页数:9
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