SOLID-PHASE SYNTHESIS OF 5-HYDROXYMETHYLURACIL CONTAINING DNA

被引：33

作者：

CONTE, MR

GALEONE, A

AVIZONIS, D

HSU, VL

MAYOL, L

KEARNS, DR

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM SOSTANZE NAT,VIA DOMENICO MONTESANO 49,I-80131 NAPLES,ITALY

[2] UNIV CALIF SAN DIEGO,DEPT CHEM,LA JOLLA,CA 92093

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(00)80660-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 3'-O-(diisopropylamino-2-cyanoethoxyphosphinyl)-5-O-(4,4'-dimethoxytrityl)-5-(tert-butyldimethylsiloxymethyl)-2'-deoxyuridine (5) and its utilization for the preparation of 5-hydroxymethyluracil (hmU) containing oligodeoxyribonucleotides by means of automated synthesis are described.

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页码：79 / 82

页数：4

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