IMMUNOHISTOLOGICAL CHARACTERIZATION OF ACUTE HERPES-SIMPLEX VIRUS-INFECTION OF LUMBAR DORSAL-ROOT GANGLIA IN THE RAT

被引：3

作者：

BLONDEAU, JM

AOKI, FY

NAGY, JI

机构：

[1] UNIV MANITOBA,DEPT PHYSIOL,WINNIPEG R3T 2N2,MANITOBA,CANADA

[2] UNIV MANITOBA,DEPT PHARMACOL & THERAPEUT,WINNIPEG R3T 2N2,MANITOBA,CANADA

[3] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG R3T 2N2,MANITOBA,CANADA

[4] UNIV MANITOBA,DEPT INFECT DIS,WINNIPEG R3T 2N2,MANITOBA,CANADA

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1993年 / 38卷 / 04期

关键词：

D O I：

10.1099/00222615-38-4-265

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

After inoculation of herpes simplex virus (HSV) into the dorsal skin of the hind paw of rats, HSV antigen was detected in dorsal root ganglion neurones by immunohistochemistry. Antigen was first detected 2 days after inoculation. Between 2 and 4 days after inoculation, numerous small-type unmyelinated neurones gave positive staining reactions for HSV antigens. Necrosis of neuronal cells was evident by 4 days. Antigen was not detected 6 or 9 days after inoculation. Immunohistological studies of co-cultivated ganglia removed from the infected monolayers, immediately after cytopathic effect first appeared or 24 h later, uniformly revealed virus antigen staining of small-type unmyelinated neuronal cells.

引用

页码：265 / 269

页数：5

共 13 条

[1] APPARENT STABILITY OF HERPES-SIMPLEX VIRUS GENOMES ISOLATED FROM PRIMARY AND RECURRENT INFECTIONS AND DORSAL-ROOT GANGLIA IN THE MOUSE [J].