学术探索
学术期刊
新闻热点
数据分析
智能评审

THE HUMAN GLIOMA PATHOGENESIS-RELATED PROTEIN IS STRUCTURALLY RELATED TO PLANT PATHOGENESIS-RELATED PROTEINS AND ITS GENE IS EXPRESSED SPECIFICALLY IN BRAIN-TUMORS

被引：116
作者：
MURPHY, EV
ZHANG, Y
ZHU, WJ
BIGGS, J
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL SURG,SAN FRANCISCO,CA 94143
[2] MCMASTER UNIV,DEPT BIOMED SCI,DIV NEUROSCI,HAMILTON,ON,CANADA
[3] UNIV ALABAMA,CTR COMPREHENS CANC,BIRMINGHAM,AL 35294
来源：
GENE | 1995年 / 159卷 / 01期
关键词：
PLANT DEFENSE-RESPONSE; CDNA; ASTROCYTOMA; GLIOBLASTOMA; IMMUNOLOGY;
D O I：
10.1016/0378-1119(95)00061-A
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, glioblastoma multiforme/astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.
引用
收藏
页码：131 / 135
页数：5
相关论文
共 15 条
12