PYROGLUTAMYL PEPTIDASE-II ACTIVITY IS NOT IN THE PROCESSES OF BULBOSPINAL TRHERGIC NEURONS

被引：9

作者：

JOSEPHBRAVO, P

FRESAN, ME

CISNEROS, M

VARGAS, MA

CHARLI, JL

机构：

[1] Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Cuernavaca, México 62271, AP 510-3, Mor

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

THYROTROPIN-RELEASING HORMONE; PYROGLUTAMYL PEPTIDASE II; ECTOPEPTIDASE; SPINAL CORD; RAPHE NUCLEUS; POSTSYNAPTIC;

D O I：

10.1016/0304-3940(94)90769-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pyroglutamyl peptidase II (PPII) is a neuronal ectoenzyme involved in released thyrotropin-releasing hormone (TRH) inactivation. In an attempt to define if it is present in the pre or postsynaptic membrane, we induced neuronal degeneration of serotonin-TRHergic cells that project from raphe nuclei to the spinal cord. 2-4 weeks after intracisternal injection of 5, 7-dihydroxytryptamine, TRH levels decreased over 70% in the cervical, thoracic or lumbar regions of spinal cord. In contrast, no change of PPII activity was observed. Longer times after injection (6-8 weeks), a 59-66% increase in activity was detected in the lumbar region. These data suggest that PPII is not localized in these TRHergic neurons but probably in the target cells.

引用

页码：243 / 246

页数：4

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