PRENYLATED FLAVANONES FROM DERRIS-LAXIFLORA

被引：10

作者：

KIM, YH ^{[1
]}

LEE, ES ^{[1
]}

KOONCHANOK, NM ^{[1
]}

GEAHLEN, RL ^{[1
]}

ASHENDEL, CL ^{[1
]}

CHANG, CJ ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

NATURAL PRODUCT LETTERS | 1995年 / 6卷 / 03期

关键词：

DERRIS LAXIFLORA; FLAVANONES; LAXIFLORIN; PROTEIN-TYROSINE KINASE; PROTEIN KINASE C;

D O I：

10.1080/10575639508043163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new prenylated flavanone 1 [laxiflorin (2S)-5,7,3',4'-tetrahydroxy-6-(beta-hydroxyethyl)-8-(gamma,gamma-dimethylallyl)flavanone] and four known flavanones (6,8-diprenyleriodictyol, hiravanone, senegalensein and lupinifolin) were isolated from the leaves and twigs of Derris laxiflora.. Laxiflorin with a beta-hydroxyethyl group at C-6 exhibited significant inhibitory activity against protein-tyrosine kinase.

引用

页码：223 / 231

页数：9

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