CLONING AND EXPRESSION OF A MYC FAMILY MEMBER FROM THE PITUITARY-GLAND OF THE RAINBOW-TROUT, ONCORHYNCHUS-MYKISS

被引：4

作者：

PANNO, JP

MCKEOWN, BA

机构：

[1] Department of Biological Sciences, Simon Fraser University, Burnaby

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 01期

关键词：

MYC GENE FAMILY; CDNA; PITUITARY GLAND; (RAINBOW TROUT);

D O I：

10.1016/0167-4781(95)00121-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A myc gene cloned from a Rainbow trout pituitary gland cDNA library is described. This clone (Tmyc?) shows extensive homology to Rainbow trout C-myc, which is expressed in the liver. Tmyc2 does not appear in the liver but is expressed in the pituitary gland (1.9 kb transcript), brain (2.0 kb transcript) and, at very low levels, in the heart (2.0 kb transcript). Tmyc2 contains three highly modified areas within the coding sequence, one of which shows an extensive loss of acidic residues that is uncommon in C-myc family members and may be important in determining the function of Tmyc2 in the pituitary gland and brain.

引用

页码：7 / 11

页数：5

共 24 条

[1] ONCOGENE COOPERATION IN LYMPHOCYTE-TRANSFORMATION - MALIGNANT CONVERSION OF E-MU-MYC TRANSGENIC PRE-B CELLS-INVITRO IS ENHANCED BY V-H-RAS OR V-RAF BUT NOT V-ABL [J].