AUTOXIDATIVE FORMATION OF A CHEMICALLY REACTIVE INTERMEDIATE FROM AMODIAQUINE, A MYELOTOXIN AND HEPATOTOXIN IN MAN

被引:35
作者
MAGGS, JL [1 ]
KITTERINGHAM, NR [1 ]
BRECKENRIDGE, AM [1 ]
PARK, BK [1 ]
机构
[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,ENGLAND
关键词
D O I
10.1016/0006-2952(87)90130-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:2061 / 2062
页数:2
相关论文
共 14 条
  • [1] DISPOSITION AND METABOLISM OF AMODIAQUINE IN SMALL MAMMALS
    BARROW, A
    [J]. XENOBIOTICA, 1974, 4 (11) : 669 - 680
  • [2] SYNTHESIS, DECOMPOSITION KINETICS, AND PRELIMINARY TOXICOLOGICAL STUDIES OF PURE N-ACETYL-P-BENZOQUINONE IMINE, A PROPOSED TOXIC METABOLITE OF ACETAMINOPHEN
    DAHLIN, DC
    NELSON, SD
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) : 885 - 886
  • [3] N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN
    DAHLIN, DC
    MIWA, GT
    LU, AYH
    NELSON, SD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05): : 1327 - 1331
  • [4] HATTON CSR, 1986, LANCET, V1, P411
  • [5] HINSON JA, 1980, DRUG METAB DISPOS, V8, P289
  • [6] LARSSON R, 1986, CHEM BIOL INTERACT, V52, P1
  • [7] LOOAREESUWAN S, 1985, LANCET, V2, P805
  • [8] LOWRY OH, 1951, J BIOL CHEM, V193, P265
  • [9] MAGGS JL, IN PRESS BR J CLIN P
  • [10] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF AMODIAQUINE IN HUMAN-PLASMA
    MIHALY, GW
    NICHOLL, DD
    EDWARDS, G
    WARD, SA
    ORME, ML
    WARRELL, DA
    BRECKENRIDGE, AM
    [J]. JOURNAL OF CHROMATOGRAPHY, 1985, 337 (01): : 166 - 171