NOOTROPIC ACTIVITY OF ISORHAMNETIN IN AMYLOID BETA 25-35 INDUCED COGNITIVE DYSFUNCTION AND ITS RELATED mRNA EXPRESSIONS IN ALZHEIMER'S DISEASE

被引：6

作者：

Asha, Deivasigamani ^{[1
]}

Sumathi, Thangarajan ^{[1
]}

机构：

[1] Univ Madras, Dept Med Biochem, Dr ALM Post Grad Inst Basic Med Sci, Taramani Campus, Chennai 600113, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2016年 / 7卷 / 08期

关键词：

Y-arm; proinflammatory cytokine; iNOS; ChAT;

D O I：

10.13040/IJPSR.0975-8232.7(8).3233-42

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Oxidative stress appears to be an early event involved in the pathogenesis of Alzheimer's disease. The present study was designed to investigate the neuroprotective effects of isorhamnetin (IRN) against amyloid beta 25-35 (A beta 25-35)-induced memory impairment and oxidative damage in rats. Memory task was assessed using Y-arm maze and it revealed the impairment in spatial memory. The IRN treated rats showed improvement in memory task. A beta 25-35 induced animals also exhibited increase in hydrogen peroxide (H2O2), Monoamine oxidase activity (MAO) and decrease in choline acetyltransferase (ChAT) activity. It also enhanced the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokine, IL-beta whereas all these abnormalities were reduced significantly in IRN treated rats showing the neuroprotective effect of IRN against A beta 25-35 induced Alzheimer's disease (AD). Thus, IRN may be a potential therapeutic agent for Alzheimer's disease.

引用

页码：3233 / 3242

页数：10

共 53 条

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Restraining tumor necrosis factor-alpha by thalidomide prevents the Amyloid beta-induced impairment of recognition memory in mice [J].