CYCLOTRON PRODUCTION OF CARRIER-FREE COBALT-55, A NEW POSITRON-EMITTING LABEL FOR BLEOMYCIN

被引：54

作者：

LAGUNASSOLAR, MC

JUNGERMAN, JA

机构：

[1] Crocker Nuclear Laboratory, University of California, Davis, CA

来源：

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1979年 / 30卷 / 01期

关键词：

D O I：

10.1016/0020-708X(79)90093-0

中图分类号：

TL [原子能技术]; O571 [原子核物理学];

学科分类号：

0827 ; 082701 ;

摘要：

A method for producing carrier-free 55Co (18.5 h) by proton bombardment of natural iron targets is presented. 55Co is formed primarily by means of the 56Fe (p, 2n)55Co reaction. Thin-target and thick-target yields as well as cross-section calculations are given in the 15-MeV to 40-MeV proton-energy range. Half-life measurements indicate a value of 18.5 h for 55Co. Chemical purification of the 55Co from the iron target is described. 56Co, 52Mn, and 54Mn were found as radionuclidic impurities in the final preparation. The 55Co solution contains less than 0.5 μg/ml of iron contamination. Synthesis of 55Co-bleomycin results in better than 99% labeling yield. © 1979.

引用

页码：25 / 32

页数：8

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