THE EFFICACY AND LONG-TERM TOLERABILITY OF LAMOTRIGINE IN THE TREATMENT OF SEVERE EPILEPSY

被引：64

作者：

SANDER, JWAS ^{[1
]}

TREVISOLBITTENCOURT, PC ^{[1
]}

HART, YM ^{[1
]}

PATSALOS, PN ^{[1
]}

SHORVON, SD ^{[1
]}

机构：

[1] INST NEUROL,INSEG,EPILEPSY RES GRP,LONDON WC1N 3BG,ENGLAND

来源：

EPILEPSY RESEARCH | 1990年 / 7卷 / 03期

关键词：

Lamotrigine; Long-term evaluation; New antiepileptic drug; Refractory epilepsy;

D O I：

10.1016/0920-1211(90)90019-R

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the effects of the addition of lamotrigine, a novel antiepileptic drug, to the therapy of 125 patients with severe refractory epilepsy. Forty-five patients (36%) reported adverse experiences and in 19 (15%), the drug was withdrawn. The commonest adverse experiences were diplopia, headache, ataxia, drowsiness, skin rash and deterioration in seizure control. Two patients were withdrawn for other reasons. The remaining 104 patients were followed for a mean of 11 months (range 3-27): 26 (25%) of these showed a marked improvement in seizure frequency (a 50% or more reduction when compared with the pre-trial period), but no patient was rendered seizure-free. Tolerance to the effects of the drug was not seen. © 1990.

引用

页码：226 / 229

页数：4

共 8 条

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[5] Loiseau, Yuen, Duche, Menager, Arne-Bes, A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures, Epilepsy Res., 7, pp. 136-145, (1990)
[6] Miller, Sawyer, Roth, Peck, Leach, Wheatley, Parsons, Morgan, Lamotrigine, New Anticonvulsant Drugs, pp. 165-177, (1986)
[7] Miller, Wheatley, Sawyer, Baxter, Roth, Pharmacological studies on lamotrigine a novel potential antiepileptic drug I Anticonvulsant profile in mice and rats, Epilepsia, 27, pp. 483-489, (1986)
[8] Sander, Patsalos, Oxley, Hamilton, Yuen, A randomised double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy, Epilepsy Res., 6, pp. 221-226, (1990)

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