ERYTHROPOIETIN RESPONSE TO ANEMIA AS A FUNCTION OF AGE

被引：41

作者：

POWERS, JS

KRANTZ, SB

COLLINS, JC

MEURER, K

FAILINGER, A

BUCHHOLZ, T

BLANK, M

SPIVAK, JL

HOCHBERG, M

BAER, A

COTES, PM

GOLDWASSER, E

机构：

[1] SUNY BUFFALO,DEPT MED,BUFFALO,NY 14260

[2] SUNY BUFFALO,DEPT RHEUMATOL,BUFFALO,NY 14260

[3] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

[4] ROBERT WOOD JOHNSON PHARMACEUT RES INST,RARITAN,NJ

[5] VET ADM MED CTR,BUFFALO,NY 14215

[6] ORTHO PHARMACEUT CORP,RARITAN,NJ 08869

[7] JOHNS HOPKINS MED INST,DEPT MED,BALTIMORE,MD 21205

[8] JOHNS HOPKINS MED INST,DEPT HEMATOL,BALTIMORE,MD 21205

[9] JOHNS HOPKINS MED INST,DEPT RHEUMATOL,BALTIMORE,MD 21205

[10] VANDERBILT UNIV,MED CTR,DEPT BIOMED ENGN,NASHVILLE,TN 37240

[11] VANDERBILT UNIV,MED CTR,DEPT HEMATOL,NASHVILLE,TN 37240

[12] VANDERBILT UNIV,MED CTR,CLIN RES CTR,NASHVILLE,TN 37240

[13] VET ADM MED CTR,NASHVILLE,TN

[14] SUNY BUFFALO,DEPT MED,BUFFALO,NY 14260

[15] SUNY BUFFALO,DEPT HEMATOL,BUFFALO,NY 14260

[16] SUNY BUFFALO,DEPT RHEUMATOL,BUFFALO,NY 14260

[17] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 1991年 / 39卷 / 01期

关键词：

D O I：

10.1111/j.1532-5415.1991.tb05902.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The erythropoietin (EPO) response to anemia was assessed for 244 subjects aged 1-64 years (mean 45.2 years) and 121 subjects aged 65-94 years (mean 68.3 years). Subjects included non-anemic individuals as well as those with anemia of various etiologies, excluding renal disease and pregnancy. Significant inverse correlations between serum immunoreactive EPO and hematocrit were noted for both groups. Regression lines failed to show a significantly lower slope or y-intercept for older compared to younger subjects. EPO level were not significantly lower for older compared to younger subjects when controlled for hematocrit level. These results suggest that the EPO response to anemia in older subjects is similar to that of younger subjects.

引用

页码：30 / 32

页数：3

共 15 条

[1] BLUNTED ERYTHROPOIETIN RESPONSE TO ANEMIA IN RHEUMATOID-ARTHRITIS [J].