SYNTHESIS, CHARACTERIZATION AND INVITRO ANTITUMOR-ACTIVITY OF DIMETHYL-TIN(IV), DIETHYL-TIN(IV) AND DI-T-BUTYL-TIN(IV) DERIVATIVES OF SUBSTITUTED SALICYLIC ACIDS

The synthesis of dimethyl-, diethyl- and/or di-t-butyl-tin(IV) derivatives of substituted salicylic acids of the type a, (X-Y-2-OH-C6H2COO)2SnR2 (X, Y = H, H; H, 5-CH3; H, 5-Cl; H, 5-F; H, 3-CH3O; H, 5-CH3O; 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) and b {[R2(X-Y-2-OH-C6H2COO)Sn]2O}2 (X, Y = H, 3-CH3O; H, 5-CH3O: 3-CH3, 6-(CH3)2CH; 3,5-[(CH3)2CH]2 and 4,5-benzo) is reported. Their characterization by H-1 C-13 and Sn-119 NMR, Mossbauer and mass spectrometry is described. The in vitro antitumor activity of selected derivatives against two human tumoral cell lines, MCF-7 and WiDr, is presented.