CARDIAC MICROCIRCULATORY EFFECTS OF BETA-ADRENERGIC-BLOCKADE DURING SYMPATHETIC-STIMULATION

被引:8
作者
COUSINEAU, DF
GORESKY, CA
ROSE, CP
SCHWAB, AJ
机构
[1] MCGILL UNIV,MONTREAL GEN HOSP,MED CLIN,ROOM 1068,1650 CEDAR AVE,MONTREAL H3G 1A4,QUEBEC,CANADA
[2] MCGILL UNIV,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA
[3] MCGILL UNIV,DEPT PHYSIOL,MONTREAL H3A 2T5,QUEBEC,CANADA
关键词
CAPILLARY PERMEABILITY SURFACE AREA PRODUCT; CAPILLARY TRANSIT TIME; MULTIPLE INDICATOR DILUTION STUDIES; BETA-ADRENERGIC BLOCKADE; SYMPATHETIC EFFECTS; CAROTID OCCLUSION;
D O I
10.1161/01.RES.68.4.997
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of beta-adrenergic blockade on cardiac transcapillary exchange were examined at rest and during sympathetic stimulation. Multiple indicator dilution experiments were carried out in closed-chest anesthetized dogs at rest and during carotid occlusion, either under basal conditions or after beta-adrenergic blockade with alprenolol. Beta-Adrenergic blockade at rest had no effect on coronary flow or transcapillary exchange in comparison with the control situation, but it abolished the increase in coronary flow and in the permeability/surface area product for labeled sucrose produced by carotid occlusion. High coronary resistance values in beta-blocked animals with carotid occlusion were associated with a high degree of heterogeneity in capillary transit times, but the overall relation between coronary flow and the capillary permeability/surface area product was unchanged. The findings indicate that beta-blockade increases coronary resistance during sympathetic stimulation and, simultaneously, decreases the coronary blood flow and capillary permeability/surface area product while increasing the heterogeneity of capillary transit times.
引用
收藏
页码:997 / 1006
页数:10
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