CLONAL ABERRATIONS OF CHROMOSOMES-X, CHROMOSOME-Y, CHROMOSOME-7 AND CHROMOSOME-10 IN NORMAL KIDNEY TISSUE OF PATIENTS WITH RENAL-CELL TUMORS

被引：61

作者：

EMANUEL, A

SZUCS, S

WEIER, HUG

KOVACS, G

机构：

[1] UNIV FREIBURG,INST PATHOL,CYTOGENET LAB,W-7800 FREIBURG,GERMANY

[2] UNIV CALIF LAWRENCE LIVERMORE NATL LAB,DIV BIOMED SCI,LIVERMORE,CA 94550

[3] NCI,FREDERICK CANC RES & DEV CTR,DYNCORP,PROGRAM RESOURCES INC,FREDERICK,MD 21701

来源：

GENES CHROMOSOMES & CANCER | 1992年 / 4卷 / 01期

关键词：

D O I：

10.1002/gcc.2870040110

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7- and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo.

引用

页码：75 / 77

页数：3

共 18 条

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