EFFECTS OF SAPONINS FROM MIMOSA-TENUIFLORA ON LYMPHOMA-CELLS AND LYMPHOCYTES

被引：16

作者：

JIANG, YL

WENIGER, B

HAAGBERRURIER, M

ANTON, R

BECK, JP

ITALIANO, L

机构：

[1] FAC PHARM ILLKIRCH,PHARMACOGNOSIE LAB,BP 24,F-67401 ILLKIRCH GRAFFENS,FRANCE

[2] INST HEMATOL,F-67091 STRASBOURG,FRANCE

来源：

PHYTOTHERAPY RESEARCH | 1992年 / 6卷 / 06期

关键词：

MIMOSA-TENUIFLORA; MIMOSACEAE; SAPONINS; MIMONOSIDE-A; MIMONOSIDE-B AND MIMONOSIDE-C; MOLT-4; RDM-4; THYMOCYTES; SPLENOCYTES; LYMPHOCYTE PROLIFERATION; MITOGEN;

D O I：

10.1002/ptr.2650060606

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The following saponosides: mimonosides A (Ma), B (Mb) and C (Mc), isolated from the bark of Mimosa tenuiflora (Willd.) Poiret (Mimosaceae) were tested for their influence on cell growth. These effects were evaluated in vitro on a panel of lymphoma cells from human and murine origins and on murine lymphocytes (thymocytes and splenocytes). The three saponins did not exhibit any growth influence on two tumour cell lines (Molt 4 and RDM 4). However, they exhibit an important increase of incorporation of tritiated thymidine into DNA of cultured lymphocytes in vitro. Synergic effects of the saponins with concanavaline A (Con A) and lipopolysaccharide (LPS) on the lymphocytes were observed.

引用

页码：310 / 313

页数：4

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