SEVERE ANAPHYLACTIC SHOCK DUE TO REPEATED APPLICATION OF APROTININ IN PATIENTS FOLLOWING INTRATHORACIC AORTIC REPLACEMENT

被引:37
作者
SCHULZE, K [1 ]
GRAETER, T [1 ]
SCHAPS, D [1 ]
HAUSEN, B [1 ]
机构
[1] HANNOVER MED SCH,DEPT ANESTHESIOL,KONSTANTY GUTSCHOW STR 8,D-30623 HANNOVER,GERMANY
关键词
APROTININ; ANAPHYLACTIC SHOCK; AORTIC DISSECTION; CARDIOPULMONARY RESUSCITATION;
D O I
10.1016/1010-7940(93)90280-O
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aprotinin is known to significantly reduce the incidence of perioperative bleeding complications in cardiac, thoracic and vascular surgery. Despite the wide use of this medication in other surgical fields, there are only a few reports of serious adverse side effects. In this paper we report on two patients with severe anaphylactic shock due to repeated administration of aprotinin, who both required cardiopulmonary resuscitation.
引用
收藏
页码:495 / 496
页数:2
相关论文
共 10 条
[1]  
Bidstrup B.P., Royston D., Sapsford R.N., Taylor K.M., Cosgrove D.M., Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol), J Thorac Cardiovasc, 97, pp. 364-372, (1989)
[2]  
Bohrer H., Bach A., Fleischer F., Lang J., Adverse haemodynamic effects of high-dose aprotinin in a paediatric cardiac Surgical patient, Anaesthesia, 45, pp. 853-854, (1990)
[3]  
Dietrich W., Spannagl M., Jochum M., Wendt P., Schramm W., Barankay A., Sebening F., Richter J.A., Influence of high dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization, Anesthesiology, 73, pp. 1119-1126, (1990)
[4]  
Freeman J.G., Turner G.A., Venables C.W., Latner A.L., Serial use of aprotinin and incidence of allergic reactions, Curr Med Res Opin, 8, pp. 559-561, (1983)
[5]  
Fritz H., Die Zielenzyme des Aprotinin in vitro und in vivo. In: Dudziak R, Kirchhoff PG, (1985)
[6]  
Schattauer G., Stuttgart Haberland G.L., Matis P., Trasylol, ein Proteinasenin hibitor bei chirurgischen und internen Indikationen, Medizini Sche Welt, 18, pp. 1367-1376, (1967)
[7]  
Harke H., Hutkijper A., Rahman S., Der EinfluD von Aprotinin auf die intra- und postoperative Histaminfreisetzung und Hiimostase, Anlsthesist, 37, pp. 489-497, (1988)
[8]  
Nagaoka H., Innami R., Murayama F., Funakoshi N., Hirooka K., Watanabe M., Satoh M., Effects of aprotinin on prostaglandin metabolism and platelet function in open heart surgery, J Cardiovasc Surg, 32, pp. 31-37, (1991)
[9]  
Royston D., Bidstrup B.P., Taylor K.M., Sapsford R.N., Effect of aprotinin on need for blood transfusion after repeat openheart surgery, Lancet II, pp. 1289-1291, (1987)
[10]  
Verstraete M., Clinical application of inhibitors of tibrinolysis, Drugs, 29, pp. 236-261, (1985)