REGIONAL LOCALIZATION OF THE HUMAN VITRONECTIN RECEPTOR ALPHA SUBUNIT GENE (VNRA) TO CHROMOSOME-2Q31-]Q32

被引：8

作者：

FERNANDEZRUIZ, E ^{[1
]}

DEVILLENA, FPM ^{[1
]}

DECORDOBA, SR ^{[1
]}

SANCHEZMADRID, F ^{[1
]}

机构：

[1] CSIC,CTR INVEST BIOL,MADRID 6,SPAIN

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 62卷 / 01期

关键词：

D O I：

10.1159/000133437

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vitronectin receptor (alphav:beta3; CD51/CD61), a member of the beta3 integrin subfamily (cytoadhesins), functions as a receptor for a group of proteins that includes vitronectin. fibrinogen, thrombospondin, and von Willebrand factor. The human locus for the alphav gene (VNRA) was previously mapped to the long arm of chromosome 2 by DNA analysis of somatic cell hybrids. By using fluorescence in situ hybridization, coupled with GTG-banding, we have regionally mapped the human alphav gene to chromosome 2q31 --> q32. An identical location was previously reported for the human gene coding for the integrin VLA-alpha4 subunit (CD49D). These data, therefore, suggest the existence of a cluster of integrin genes at this chromosomal location.

引用

页码：26 / &

共 27 条

[21]

SOSNOSKI DM, 1988, J CLIN INVEST, V81, P1983

[22] ADHESION RECEPTORS OF THE IMMUNE-SYSTEM [J].