SYNTHESIS AND CHARACTERIZATION OF NEW POLYETHYLENEOXY SUBSTITUTED SALICYLALDIMINE SCHIFF-BASES AND SOME CORRESPONDING REDUCED TETRA-AZA AND PENTA-AZA LIGANDS AND THEIR GADOLINIUM(III) COMPLEXES - NEW POTENTIAL CONTRAST AGENTS IN MAGNETIC-RESONANCE-IMAGING

被引：20

作者：

KOCIAN, O

CHIU, KW

DEMEURE, R

GALLEZ, B

JONES, CJ

THORNBACK, JR

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] ZONING IND,MEDGENIX DIAGNONIST,B-6220 BRUSSELS,BELGIUM

[3] UNIV LOUVAIN,DEPT RADIOL,B-1200 BRUSSELS,BELGIUM

[4] UNIV LOUVAIN,DEPT PHARMACEUT SCI,B-1200 BRUSSELS,BELGIUM

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 05期

关键词：

D O I：

10.1039/p19940000527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of polyether substituted salicylaldehyde derivatives OHCC6H3OH-2-OR-3 [R = CH2-(CH2OCH2)(n)CH(2)OR', n = 1, 4 and R' = Me; n = 5 and R'= H] have been synthesised and used to prepare the polydentate ligands HN[(CH2CH2NHCH2CH2N=CHC6H3OH-2-OR-3](2), HN[CH2CH2NHCH2CH2NHCH2C6H3-OH-2-OR-3](2) and HN[CH2CH2N=CHC6H3OH-2-OR-3](3); a preliminary evaluation has been made of the potential use of their gadolinium complexes as contrast agents for diagnostic Magnetic Resonance Imaging.

引用

页码：527 / 535

页数：9

共 28 条

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