IMPORTANCE OF CANDIDA SPECIES OTHER THAN CANDIDA-ALBICANS AS PATHOGENS IN ONCOLOGY PATIENTS

被引:409
作者
WINGARD, JR
机构
[1] Emory University School of Medicine, Atlanta, GA
关键词
D O I
10.1093/clinids/20.1.115
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A number of surveys have documented increased rates of candida infection over the past several decades, In this assessment of the frequency and distribution of non-albicans Candida species among patients with cancer, 37 reports that were published between 1952 and 1992 and that described 1,591 cases of systemic candida infection were reviewed. Species other than Candida albicans accounted for 46% of ail systemic candida infections in patients with cancer; specifically, Candida tropicalis accounted for 25%, Candida glabrata for 8%, Candida parapsilosis for 7%, and Candida krusei for 4%, Other species were uncommon, C. tropicalis was the predominant pathogenic Candida species in five reports, C. glabrata in two, C krusei in two, and Candida stellatoidea in one, The perception that, over time, a greater proportion of candida infections have been caused by non-albicans species was not borne out, The wide variability in reported findings was striking and was due in part to differences in the underlying diseases affecting the patients described. For example, patients with leukemia were more likely to be infected by C. albicans or C. tropicalis but less likely to be infected by C. glabrata than patients with other types of cancer, The recent increase in the rate of bone marrow transplantation may also have contributed to discrepancies among reports. Bone marrow transplant recipients were more likely to be infected by C. krusei or C. lusitaniae. The other factors partially responsible for the variability among reports included common-source contamination and the pressures imposed by antimicrobial measures.
引用
收藏
页码:115 / 125
页数:11
相关论文
共 122 条
[1]   DISSEMINATED FUNGAL DISEASE RESISTANT TO FLUCONAZOLE TREATMENT IN A CHILD WITH LEUKEMIA [J].
ABRAHAMSEN, TG ;
WIDING, E ;
GLOMSTEIN, A ;
GAUSTAD, P .
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1992, 24 (03) :391-393
[2]   TORULOPSIS-GLABRATA INFECTIONS IN PATIENTS WITH CANCER - INCREASING INCIDENCE AND RELATIONSHIP TO COLONIZATION [J].
AISNER, J ;
SCHIMPFF, SC ;
SUTHERLAND, JC ;
YOUNG, VM ;
WIERNIK, PH .
AMERICAN JOURNAL OF MEDICINE, 1976, 61 (01) :23-28
[3]  
ANAISSIE K, 1987, 27TH INT C ANT AG CH
[4]  
ANDRIOLE VT, 1962, YALE J BIOL MED, V35, P96
[5]  
BERGER C, 1988, SCHWEIZ MED WSCHR, V118, P37
[6]   FLUCONAZOLE AND CANDIDA-KRUSEI INFECTIONS [J].
BIGNARDI, GE ;
SAVAGE, MA ;
COKER, R ;
DAVIS, SG .
JOURNAL OF HOSPITAL INFECTION, 1991, 18 (04) :326-327
[7]   DETECTION OF YEASTS AND FILAMENTOUS FUNGI IN BLOOD CULTURES DURING A 10-YEAR PERIOD (1972 TO 1981) [J].
BILLE, J ;
STOCKMAN, L ;
ROBERTS, GD .
JOURNAL OF CLINICAL MICROBIOLOGY, 1982, 16 (05) :968-970
[8]  
BISTONI F, 1984, SABOURAUDIA, V22, P409
[9]   EMERGENCE OF A NEW OPPORTUNISTIC PATHOGEN, CANDIDA-LUSITANIAE [J].
BLINKHORN, RJ ;
ADELSTEIN, D ;
SPAGNUOLO, PJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (02) :236-240
[10]   FUNGAL INFECTIONS COMPLICATING ACUTE LEUKEMIA [J].
BODEY, GP .
JOURNAL OF CHRONIC DISEASES, 1966, 19 (06) :667-+