DIFFERENTIAL REGULATION OF THE 2'3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE GENE DURING OLIGODENDROCYTE DEVELOPMENT

被引：119

作者：

SCHERER, SS

BRAUN, PE

GRINSPAN, J

COLLARINI, E

WANG, DY

KAMHOLZ, J

机构：

[1] MCGILL UNIV,DEPT BIOCHEM & NEUROL,MONTREAL H3G 1Y6,PQ,CANADA

[2] CHILDRENS HOSP PHILADELPHIA,DIV NEUROL RES,PHILADELPHIA,PA 19104

[3] UNIV LONDON UNIV COLL,DEPT BIOL,LONDON WC1E 6BT,ENGLAND

来源：

NEURON | 1994年 / 12卷 / 06期

关键词：

D O I：

10.1016/0896-6273(94)90451-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The two major isoforms of 2',3'-cyclic nucleotide phosphodiesterase (CNP), 48 and 46 kDa, have recently been shown to be produced from a single gene by alternative splicing. In addition, messenger RNA encoding the larger isoform is transcribed from a separate promoter, approximately 1 kb upstream from that encoding the smaller isoform. We have investigated the expression of these two CNP isoforms and have found that they are differentially expressed during the process of oligodendrocyte maturation. In oligodendrocyte precursors, only the mRNA encoding the larger protein is found. At the time of oligodendrocyte differentiation, however, both CNP mRNAs are induced. These patterns of CNP expression are likely due to stage-specific transcriptional regulation of the two CNP promoters during the process of oligodendrocyte differentiation.

引用

页码：1363 / 1375

页数：13

共 54 条

[1] TEMPORAL EXPRESSION OF MYELIN-SPECIFIC COMPONENTS IN NEONATAL MOUSE-BRAIN CULTURES - EVIDENCE THAT 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE APPEARS PRIOR TO GALACTOCEREBROSIDE [J].