MULTIPLE CONTROL ELEMENTS REGULATE TRANSCRIPTION FROM THE MOST DISTAL PROMOTER OF HUMAN ALDOLASE-A GENE

被引：12

作者：

COSTANZO, P

LUPO, A

RIPPA, E

GROSSO, M

SALVATORE, F

IZZO, P

机构：

[1] Dipartimento di Biochimica e Biotecnologie Med, Facoltà di Medicina e Chirurgia, Universita degli Studi “Federico II”, Napoli

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three major transcripts, differing in their 5'-untranslated regions, are produced from the human aldolase A gene by alternative usage of three promoters, designated distal, middle and proximal. We report that the genomic region (distal promoter) upstream from the first leader exon (exon L1) efficiently directs transcription of a receptor CAT gene after transient transfections in human hepatoma cells (Hep3B) in a fashion independent from the other two promoters of the same gene. The distal promoter region contains cis-acting elements that regulate transcription both positively and negatively. © 1993 Academic Press, Inc.

引用

页码：935 / 944

页数：10

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